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Imitrex is a medication that comes in various forms besides the staple pills. You can buy nose sprays or injections too. The form you choose will depend on your personal preference. It is a good idea to ask the doctor her opinion on this matter too. Remember that the form does not hold importance or have any effect on its working. It is the time that matters the most. You should take this medication – in any form – immediately after getting a migraine headache. However, there are a few things that you should keep in mind while using this drug. You might feel flushing and dizziness when you take Imitrex. If you are on depression medication, this drug is not for you. A combination of Imitrex and depression medication can be life threatening. Also, you shouldn’t take this medication if you have a history of heart problems or high blood pressure or diabetes.